METIS (Mechanically Enhanced and Three-layered orIgami Structures) is a new, free and open-source, fully autonomous design algorithm for generating arbitrary nanometer-scale structures using DNA.
DNA can be programmed to robustly self-assemble into pre-defined nanoscale structures of nearly arbitrary 2D and 3D shape using the principle of scaffolded DNA origami, invented by Dr. Paul Rothemund in 2006. This website offers an online portal to the METIS software that automatically converts any polygon mesh file specified using simple Computer-Aided Design into the synthetic DNA sequences that are needed to synthesize the target object. In short, METIS offers the ability to “print” your 2D nanometer-scale geometry in DNA.
For more information on our approach, please see this About page.